The genetic networks in any biological system can be only understood completely when the genetic analysis is considered along with robust phenotyping methods. Thus, genetics go hand in hand, with phenotyping. Phenomics gene function places a very essential part in different areas of science.
Different fields such as disease control, agricultural development, production of disease-free plants, or development of new medicines each field requires combined knowledge of genomics and phenomics, and thus they need to be studied together. For example, genome manipulation studies in a mouse model enable the generation of a wide variety of allelic combinations and genetic variants across their genome.
The phenotypic traits help the researcher to analyze the genetic variations and through phenotypic expansion studies genome-wide association studies (GWAS), as well as phenome-wide association studies (PheWAS), can be done and pleiotropy of an individual can be generated.
The pleiotropy works based on highly interconnected genetic networks and it will always vary based on genetic context and phenotypic criteria.
The expansion of phenotypic variations is associated with specific mutations in specific genes and it helps in the development of gene function understanding and thus helps in revealing the genetic basis of disease.
Concept of High throughput Phenotyping
The best part of high throughput phenotyping is its association.
The variable environmental conditions also do not affect data integrity in such methods. The measurement of biomass and its growth can be done digitally with an imaging system and different probes are used in this method for understanding the physiological functioning.
The 3-D models help the researcher to understand the different variables of a phenotype and easily it can be correlated with the genetic make-up. This clarity is essentially needed when work is done at the gene level and then only, the recombinant methods can be applied and their effects can be visualized.
Harnessing Genomics through Phenomics
Genetics and genomics are revolutionary areas both in the fields of plant and animal sciences. Phenotyping is strongly influenced by genetics and it includes different practices by which the genotype of any species can be accessed.
Plant phenotyping is more common in research where different scientists have shown the phenotypic traits of plants and their relationship with their genetic constitution.
Phenotyping is considered a very tedious job because the phenotypic traits are influenced by environmental conditions and thus genotyping is easier to finish. But, the knowledge about a particular trait and its dominance is clearly can be obtained only after establishing its phenotypic relation along with phenotypic analysis.
It can be understood with a simple theory that if the genome is considered as the total genes expressed in a plant, then phenome is the sum of all expressed traits of that individual.
The expressed traits increase the interest to learn more about the functioning and origin of such traits and this interesting insight into the genotypic information and the link between these two systems.
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