The first embryonic gonad in humans can differentiate either as the testis or the ovary. This may be present inside the gonad and may not interfere with implantation in a heterosexual embryo. The primary gonad separates along the most distant line of the mesonephros. Cells in the gonadal cortex originate from mesonephros and coelomic epithelium.
The gonadal lining in female embryos remains neglected until the invasion of the germ cell. This occurs between nine to six weeks of development, although the ovarian cells are invisible for up to 13 weeks. The ovarian development shows that first sign that the emergence of germ cells that enter meiosis, thus initiating oogenesis. Oogonia is encased in cells of granulosa and the basal lamina, forming the first beads. If a follicle is not formed, oogonia deteriorate. Lack of migration of germ cells in male fetuses leads to the formation of seminiferous tubes in which spermatogonia is absent this clinical condition is referred to as “Sertoli-only syndrome”. The nature of the cell division varies between newborn males and females. Spermatogonia in the old testis meets a series of stages of mitotic cells and is eventually confined to the premeiotic state. During puberty, the process of sperm maturation involves a series of meiotic separation. Oogonia in the first uterus meet a series of mitotic stages and then enters meiosis, where it is bound to the dictyotene state before the formation of the first polar body. During adolescence, oogenesis resumes, moving through a series of meiotic stages and ovulation. This process of cell loss continues in a woman’s life. Ovulation occurs only in 400-500 oocytes, and the rest is lost with atresia.
Gene regulating sexual differentiation:
There are two primary ducts known as paramesonephric ducts and mesonephric ducts. These two ducts act as a precursor for the female reproductive system and male genitalia. When the development initiatives, one of these duct develops and another one gets inhibited. The gene present regulates this all present on the y chromosome known as SRY gene.
The differentiation of wonder and inhibition of other is regulated by the presence of the two hormones known as testosterone and anti-mullerian hormone. Any dys functioning of the development may affect either the development of both the ducts or none of them to get developed; this clinical condition produces intersex organisms morphologically.
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