Mitochondria are referred to as the energy factories of the body. They convert the food into the energy that is required for the regular functioning of the body. The mitochondria are responsible for the production of 90% of the energy that is utilized by the body. The mitochondrial dysfunction diseases are chronic and genetic disorders. These are inheritable from the parents to the children. Mitochondrial diseases can be present since birth and can also be caused in the course of life. These diseases can affect any organ and part of the body. These comprise the brain cells, nerve cells, muscle cells, eyes, liver, heart, kidneys, ears, and pancreas. The mitochondrial dysfunctions with the improper functioning of the mitochondria. These can also be due to other diseases. The mitochondrial diseases comprise Alzheimerâ€™s disease that affects the brain, Lou Gehrigâ€™s disease, a disease that affects the muscles- muscular dystrophy, cancer, and also diabetes. The individuals suffering from a secondary mitochondrial dysfunction cannot be affected by the primary mitochondrial dysfunction. These patients do not have to be concerned with the growing symptoms or worsening of the symptoms. It is proved in a study that every 1 in 5000 individuals suffers from mitochondrial genetic diseases. Every year around 1000-4000 children in the United States of America are born with mitochondrial diseases. The type of mitochondrial disease depends on the systems and the affected organs. Mitochondrial diseases are generally misinterpreted as common diseases.
The primary mitochondrial diseases are genetic and are transmissible from one generation to the other in various ways. Genes are a part of the DNA (deoxyribonucleic acid) that are compressed to form the chromosomes. These genes are responsible for various traits in the species. These traits comprise hair, eye color, height, and other disorders. The genes and the DNA are considered as the blueprint of a person that describes his/her traits. Generally, genetic diseases are caused by the inheritance of defective gene pairs from the parent to the progeny, but in the case of mitochondrial diseases, only mutated pairs of genes are transmitted from generation to generation. Mitochondrial diseases are caused by the following reasons:
1. Autosomal recessive inheritance: In this case, if the progeny receives a mutated copy of the gene from both the parents, then there are 25% chances that the progeny will inherit the mitochondrial diseases.
2. Autosomal dominant inheritance: In this case, if the progeny receives one mutated copy of the gene from any one of the parents, then there are 50% chances that the progeny will inherit the mitochondrial diseases.
3. Mitochondrial inheritance: The mitochondria have their DNA and are heritable. The mitochondrial DNA is inherited from the maternal DNA or genes. The mutations in the mitochondrial DNA caused 100% transmission of the diseases to the progenies.
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